Investigation of Renal Protective Effects of Bryophyllum pinnatum (Lam) Extract in Acetaminophen Induced Toxicity in Albino Rats

Odangowei Ogidi; Ileimokumo Ogregade; Seikegba Joshua

doi:10.55940/medphar202485

Authors

Odangowei Ogidi Bayelsa Medical University
Esqure Bayelsa Medical University
Michael Bayelsa Medical University

DOI:

https://doi.org/10.55940/medphar202485

Keywords:

Bryophyllum pinnatum, Renal, Electrolytes, Biomarkers, Serum, Kidney, Acetaminophen, Albino rats

Abstract

Background: Acetaminophen is strongly linked to a notable rise in the likelihood of developing new kidney damage. Thus affecting the kidney and its biomarkers, as it a vital organ in the removal of toxicant from the body.

Objective: The research assessed renal biomarkers such as serum electrolytes (Na⁺, K⁺), chloride, bicarbonate, creatinine and urea in acetaminophen induced toxicity in albino rats and also observed the activities of these biomarkers in the albino rats when treated with Bryophyllum pinnatum.

Methods: Twenty-five (25) healthy male albino rats weighing between 150-200g were randomly grouped into five (5) groups (n-6) in a standard plastic rat cage and were pre-treated as follows: group I served as normal control: distilled water, group II served as positive control: acetaminophen (2g/kg) + distilled water. Group III served as treatment group 1: acetaminophen (2g/kg) + plant extract (200 mg/kg b.wt), group IV served as treatment group 2: acetaminophen (2g/kg) and plant extract (400 mg/kg b.wt) and group V served as standard Control: acetaminophen (2g/kg) and vitamin E (200 mg/kg b.wt) all for 14 days.

Results: There was significant increase in the concentration of serum electrolytes, creatinine, urea and chloride and a decrease in serum bicarbonate concentration when intoxicated with acetaminophen. However, treatment with Bryophyllum pinnatum at various doses with regards to body weight (200mg/kg and 400mg/kg), Vitamin E at 200mg/kg; yielded positive response in activities of these renal biomarkers.

Conclusion: The study showed that the administration of Bryophyllum pinnatum leaf extracts reduced the acetaminophen induced changes in kidney function parameters. Thus satisfying the renal protective effects of Bryophyllum pinnatum.

Keywords: Bryophyllum pinnatum, Renal, Electrolytes, Biomarkers, Serum, Kidney, Acetaminophen, Albino rats.

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