Pharmacists' knowledge and attitudes toward Pharmacogenomics in Zawia, Libya

Authors

  • Ebtesam A. Beshna Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Zawia- Libya.
  • Rabab A. Alahrish Department of Biomedical Science, Faculty of Pharmacy, University of Zawia- Libya.

DOI:

https://doi.org/10.55940/medphar202355

Keywords:

attitude, Cross-Sectional Studies, Libya, Pharmacogenetics, Iatrogenic Disease

Abstract

Background: Pharmacogenomics became essential in pharmacy practice, focusing on the effect of genome variants on patients' drug response. It aims to optimize pharmacotherapy and minimize the side effects of medications. Pharmacists play a crucial role in providing pharmacogenomic services.

Objective: To assess knowledge and attitudes toward pharmacogenomics among pharmacists in Zawia, Libya.

Methods: A cross-sectional study was carried out among community pharmacies. Participants were asked to answer a 21-closed ended questions to evaluate their knowledge and attitude regarding pharmacogenomics.

Results:  The total number of respondents was 50. A bout two third of participants 64% had bachelor degree and 62% learned about pharmacogenomics from university lectures. Slightly more than half 54% thought that the information they received about PGx enabled them to understand the effect of genetic variants on drug response. Most (>50) participants knew that human genetics can affect the response, interindividual variation, and inter-ethnic variations in drug response. A total of 68%of participants knew that PGx has an important role in identifying drug- drug interaction. However, only 36% knew that FDA provides clinical evidence for PGx testing in the labeling of many drugs. The majority of respondents 84% believed that PGx testing can improve their future work in choosing the right drug. Nevertheless, half of respondents wanted to apply PGX in their future work and 46% of participants wanted to know more about PGx.

Conclusion: Our findings revealed that pharmacists in Zawia had fair knowledge and positive attitudes towards PGx. PGx education is required to support the implementation such a valuable service into clinical practice in Libya

References

Muzoriana N, Gavi S, Nembaware V, Dhoro M, Matimba A. Knowledge, attitude, and perceptions of pharmacists and pharmacy students towards pharmacogenomics in Zimbabwe. Pharmacy. 2017;5(3):36. 10.3390/pharmacy5030036

Abubakar U, Subramaniam L, Ayinla A, Ambali MN, Mohamed Noor DA, Daud NA, Isah HK, Al-Shami HA. Knowledge, attitude and perception of community pharmacists towards pharmacogenomics services in northern Nigeria: a cross-sectional study. Journal of Pharmaceutical Policy and Practice. 2022;15(1):39. 10.1186/s40545-022-00435-x

Mahdi LA, Kadhim DJ, Al-Jumaili AA. Knowledge, Perception and Attitude Regarding Generic Medicines among Iraqi Physicians. Innov Pharm. 2020 Feb 7;11(1):10.24926/iip.v11i1.2332. DOI: 10.24926%2Fiip.v11i1.2332

Al-Hussaniy HA, Hassan AF, Oraibi AI, Al-Juhaishi AM, Naji FA, Al-Tameemi ZS. Clinical Pharmacogenetics of Angiotensin II Receptor Blockers in Iraq. Journal of Pharmacy and Bioallied Sciences. 2023;15(3):101-6. DOI: 10.4103/jpbs.jpbs_313_23

Kisor DF, Petry NJ, Bright DR. Pharmacogenomics in the United States community pharmacy setting: the clopidogrel-CYP2C19 example. Pharmacogenomics and Personalized Medicine. 2021:569-77. DOI: 10.2147/PGPM.S224894

Hayashi M, Hamdy DA, Mahmoud SH. Applications for pharmacogenomics in pharmacy practice: A scoping review. Research in Social and Administrative Pharmacy. 2022;18(7):3094-118. 10.1016/j.sapharm.2021.08.009

Arafah A, Rehman MU, Syed W, Babelghaith SD, Alwhaibi A, Al Arifi MN. Knowledge, attitude and perception of pharmacy students towards pharmacogenomics and genetics: an observational study from King Saud University. Genes. 2022;13(2):269. DOI: 10.3390/genes 13020269

Nie X, Jia T, Hu X, Li S, Zhang X, Wu C, Zhang Y, Chen J, Shi L, Lu CY. Clinical Pharmacists' Knowledge of and Attitudes toward Pharmacogenomic Testing in China. Journal of Personalized Medicine. 2022;12(8):1348. 10.3390/jpm12081348

Just KS, Steffens M, Swen JJ, Patrinos GP, Guchelaar HJ, Stingl JC. Medical education in pharmacogenomics—results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx). European journal of clinical pharmacology. 2017;73:1247-52. DOI: 10.1007/s00228-017-2292-5

Jarrar Y, Mosleh R, Hawash M, Jarrar Q. Knowledge and attitudes of pharmacy students towards pharmacogenomics among universities in Jordan and west bank of Palestine. Pharmacogenomics and Personalized Medicine. 2019:247-55. 10.2147/PGPM.S222705

Alhaddad ZA, AlMousa HA, Younis NS. Pharmacists' knowledge, and insights in implementing pharmacogenomics in Saudi Arabia. International Journal of Environmental Research and Public Health. 2022;19(16):10073. DOI: 10.3390/ijerph191610073

Beshna E, Ashour RA, Layas NA, Eldawi NS. Pharmacovigilance knowledge, attitudes, and practices of pharmacists in Zawia (Libya). Medical and Pharmaceutical Journal. 2023 Jun 30;2(2):99-106. DOI: 10.55940/medphar202347

Alexander KM, Divine HS, Hanna CR, Gokun Y, Freeman PR. Implementation of personalized medicine services in community pharmacies: perceptions of independent community pharmacists. Journal of the American Pharmacists Association. 2014;54(5):510-7. DOI: 10.1331/JAPhA.2014.13041

Shah S, Hanif M, Khan HU, Khan FU, Abbas G, Khurram H, Khames A, Abdelgawad MA, Said AS, Abourehab MA, Maheen S. Knowledge, attitudes and practices of pharmacogenomics among senior pharmacy students: a cross sectional study from Punjab, Pakistan. Pharmacogenomics and Personalized Medicine. 2022 :429-39. DOI: 10.2147/PGPM.S359920

Abu Hajleh MN, AL-Samydai AM, Mare’i MN, Abd MM, Sibai OA, Mohammed AH, Al-Sharbatee SM, Yousif RO. The role of pharmacist in guiding the pharmacy clients towards pharmaceutical preparations use. Journal of Pharmaceutical Health Services Research. 2023;14(1):28-34. 10.1093/jphsr/rmac055

Bagher AM, Neamatallah T, Balto G, Almikhy L, Almutairi SS, Abushal MO, Baghlaf K, Bagher SM. Knowledge, perception, and confidence of hospital pharmacists toward pharmacogenetics in Jeddah, Kingdom of Saudi Arabia. Saudi Pharmaceutical Journal. 2021 Jan 1;29(1):53-8. DOI: 10.1016/j.jsps.2020.12.006

Karuna N, Tragulpiankit P, Mahasirimongkol S, Chumnumwat S. Knowledge, attitude, and practice towards pharmacogenomics among hospital pharmacists in Thailand. Pharmacogenetics and Genomics. 2020 Jun 1;30(4):73-80. DOI: 10.1097/FPC.0000000000000399

Albassam A, Alshammari S, Ouda G, Koshy S, Awad A. Knowledge, perceptions and confidence of physicians and pharmacists towards pharmacogenetics practice in Kuwait. PLoS One. 2018 Sep 5;13(9):e0203033. DOI: 10.1371/journal.pone.0203033

Downloads

Published

2023-10-10

How to Cite

Beshna , E. A., & Alahrish, R. A. (2023). Pharmacists’ knowledge and attitudes toward Pharmacogenomics in Zawia, Libya . Medical and Pharmaceutical Journal, 2(3), 158– 166. https://doi.org/10.55940/medphar202355

Issue

Section

Original Articles

Categories