Ganoderma lucidum ethanolic extract for the treatment of androgenic alopecia in rats with testosterone-induced Baldness.

Poonam Rahangdale; Anjali M. Wankhade

doi:10.55940/medphar202343

Authors

Poonam C. Rahangdale Department of Pharmacology, Vidyabharti Collage of Pharmacy Amravati, Mahar astra,444602, India
Anjali M. Wankhade Department of Pharmacology, Vidyabharti Collage of Pharmacy Amravati, Mahar astra,444602, India

DOI:

https://doi.org/10.55940/medphar202343

Keywords:

Androgenic alopecia, Hair growth, Ethanolic extract of Ganoderma lucidum, follicular density, testosterone, Minoxidil 2%

Abstract

ABSTRACT
Many people worldwide suffer from alopecia. The current study's objective was to investigate the hair growth-promoting properties of a preparation containing an ethanolic extract of Ganoderma lucidum and its primary components on hair regeneration using a model of testosterone-induced alopecia. The five groups of rats tested were: negative control group (n = 6); positive control group (n = 6); testosterone plus minoxidil 2% (n = 6); testosterone and ethanolic extract of Ganoderma lucidum extract (10 mg/kg) (n = 6); and testosterone and ethanolic extract of Ganoderma lucidum extract (15 mg/kg). day-inducing substance to all groups except the negative control group, subcutaneous testosterone (1 mg/kg Sc) was administered for 21 straight days. Prior to 1 hour, the standard group received topical application of 2% minoxidil, EEGL at 10 mg/kg and 15 mg/kg, respectively. Following 21 days, a photograph was taken to document the variations in hair development between each group. After the study was finished, all of the animals were slaughtered, and the area was subsequently examined for various characteristics to gauge hair development. Anagen telogen ratio and the number of follicles per square millimetre were measured and reported. Anagen/telogen (A/T) ratio, follicular density, and hair length were all higher in the standard. EEGL 10mg/kg and EEGL 15mg/kg treatment groups were evaluated in comparison to a positive control group. The anagen/telogen ratio of the hair follicles as well as their quantity and shape both increased in EEGL. Through the return of normal parameters, the EEGL was able to promote hair growth. Compared to EEGL10mg/kg, EEGL15mg/kg produced more favourable outcomes. Its outcomes were equivalent to those of Minoxidil 2% solution, a commonly recommended drug used to encourage hair growth in persons with androgenetic alopecia.

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