The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis

Abstract

In addition to energy storage, the adipose tissue plays multiple important roles, particularly the secretion of biomolecules such as leptin that participate in the neuroendocrine regulation of appetite. Therefore, this review sought to understand the influence of leptin on the genesis of obesity. A systemic review of  the literature was conducted using articles published in English between 2016 and 2022. Ten experimental studies that introduced new approaches for treating leptin-resistant individuals were selected. The results showed that a structured food plan with a negative energy balance combined with a regular physical activity routine remains the best way to combat obesity and leptin resistance problems. It is possible to conclude that leptin resistance contributes to maintaining obesity. However, to date, there remains a lack of evidence that demonstrates a direct relationship between the poor function of this peptide and the genesis of obesity.