A Systematic review and meta-analysis of cohorts on enoxaparin dosing regimens in adult hospitalized patients

Heba Ramadan

doi:10.55940/medphar202479

Authors

Heba Ramadan Pharmacy Department, Agamy Medical District, Ministry of Health and Population, Alexandria, Egypt

DOI:

https://doi.org/10.55940/medphar202479

Keywords:

enoxaparin, low-molecular-weight heparin, dosing, hospitalized patients

Abstract

Background Enoxaparin, a low-molecular-weight heparin, is widely used for hospitalized patients for prophylaxis and situations associated with ischemic complications due to its anticoagulant and anti-inflammatory effects. In this study, enoxaparin dosage regimens are demonstrated to show adherence to the standard dose in different conditions. Methods This was applied through searching in Scopus, WOS, and Pubmed. A PRISMA checklist was followed. Quality assessment was checked. Statistical and meta-analysis were conducted by SPSS, Version 28 and the R-4.3.2 package. Results Seventeen retrospective cohort studies were included in the final analysis. Eight studies concerned COVID-19 patients. The total number of patients in the non-COVID-19 group studies is 28233; 15421 (49%, 0.4-0.59 95% C.I.) of them received a standard dose. The total number of patients in the COVID-19 group studies is 54099; no patients received a reduced dose; and 38006 (60%, 0.45-0.74 95% C.I.) received a standard dose. For non-COVID 19 studies, there is a significant difference in the means of patient number percentage received standard dose or reduced dose and those received overdose (Sig.<0.05, C.I. 95%) in favor of the standard dose or reduced dose and no significant difference in the means of patient number percentage received standard dose and those received reduced dose (Sig. = 0.56, C.I. =95%). For COVID-19 studies, there is no significant difference in the means of patient number percentage received standard dose and those received overdose (Sig. =0.094 , C.I. =95%). Conclusion Using definite tools to determine the most safe and effective enoxaparin dosage regimens is required.

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