The Role of Obesity in Cancer Incidence, Treatment, And Outcomes
DOI:
https://doi.org/10.55940/medphar202340Keywords:
Cancer, cancer incidence, cancer treatment, obesity, , obesity and cancer relationshipAbstract
Background:Obesity has become a significant public health issue worldwide and is associated with several chronic diseases, including cancer. Several epidemiological studies have reported that obesity is linked to increased cancer incidence, particularly in breast, colon, endometrial, kidney, ovarian, pancreatic, and prostate cancers. Therefore, the management of obesity may play a crucial role in cancer prevention and treatment. This review article aims to provide a comprehensive overview of the relationship between obesity and cancer incidence, treatment, and outcomes.
Method: The authors thoroughly analyzed existing epidemiological studies to examine the association between obesity and various types of cancer. They also reviewed the literature to understand the potential mechanisms through which obesity contributes to cancer development.
Result: The review found that obesity is strongly linked to an increased incidence of several types of cancer, including breast, colon, endometrial, kidney, ovarian, pancreatic, and prostate cancers. Moreover, obesity can negatively impact cancer treatment outcomes, increasing the risk of complications and treatment-related side effects.
Conclusion: The findings of this review emphasize the critical role of managing obesity in cancer prevention and treatment. Lifestyle interventions and weight management strategies should be implemented to reduce the risk of obesity-related cancers. Additionally, healthcare professionals should be aware of the potential challenges associated with treating obese cancer patients and take appropriate measures to minimize treatment-related complications
Aim: This review article aims to provide a comprehensive overview of the relationship between obesity and cancer incidence, treatment, and outcomes.
Material and Methods: The authors conducted a thorough analysis of existing epidemiological studies to examine the association between obesity and various types of cancer. They also reviewed the literature to understand the potential mechanisms through which obesity contributes to cancer development.
Results: The review found that obesity is strongly linked to an increased incidence of several types of cancer, including breast, colon, endometrial, kidney, ovarian, pancreatic, and prostate cancers. Moreover, obesity can negatively impact cancer treatment outcomes, increasing the risk of complications and treatment-related side effects.
Conclusions: The findings of this review emphasize the critical role of managing obesity in both cancer prevention and treatment. Lifestyle interventions and weight management strategies should be implemented to reduce the risk of obesity-related cancers. Additionally, healthcare professionals should be aware of the potential challenges associated with treating obese cancer patients and take appropriate measures to minimize treatment-related complications.
References
Khalid SI, Maasarani S, Wiegmann J, Wiegmann AL, Becerra AZ, Omotosho P, Torquati A. Association of bariatric surgery and risk of cancer in patients with morbid obesity. Annals of Surgery. 2022;275(1):1-6. DOI: 10.1097/SLA.0000000000005035
Schlottmann F, Dreifuss NH, Patti MG. Obesity and esophageal cancer: GERD, Barrett s esophagus, and molecular carcinogenic pathways. Expert review of gastroenterology & hepatology. 2020 Jun 2;14(6):425-33. DOI: 10.1080/17474124.2020.1764348
Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature reviews immunology. 2006 Oct 1;6(10):772-83. DOI: 10.1038/nri1937
Gallagher EJ, LeRoith D. Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. Physiol Rev. 2015;95(3):727-748. DOI: 10.1152/physrev.00030.2014
Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860-867.
DOI: 10.1038/nature01322
Al-hussaniy HA, Altalebi RR, Tylor FM, Naj MA, Kadhim ZS, Abu-rghaif AH. Leptin Hormone: In Brief. Medical and Pharmaceutical Journal. 2022;1(1):1-3. DOI: 10.55940/medphar20224
Schabath MB, Cote ML. Cancer progress and priorities: lung cancer. Cancer epidemiology, biomarkers & prevention. 2019 ;28(10):1563-79.
DOI:10.1158/1055-9965.EPI-19-0221
Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body fatness and cancer—viewpoint of the IARC Working Group. New England journal of medicine. 2016 ;375(8):794-8. DOI: 10.1056/NEJMsr1606602
Fontaine KR, Heo M, Bathalon GP, et al. Body mass index and cancer survival in the National Health and Nutrition Examination Survey I epidemiologic follow-up study. Cancer Epidemiol Biomarkers Prev. 2007;16(4):859-862. DOI: 10.1158/1055-9965.EPI-15-1336
Makarova-Rusher OV, Altekruse SF, McNeel TS, et al. Population attributable fractions of risk factors for hepatocellular carcinoma in the United States. Cancer. 2016;122(11):1757-1765.
Al-Hussaniy HA. The Effect of MicroRNA-409-3p for Treatment and Response to Tumor Proliferation of Lung Cancer Cell Lines (In Vitro). Asian Pacific Journal of Cancer Prevention. 2022;23(9):3151. DOI: 10.31557/APJCP.2022.23.9.3151
Ligibel JA, Alfano CM, Courneya KS, Demark-Wahnefried W, Burger RA, Chlebowski RT, Fabian CJ, Gucalp A, Hershman DL, Hudson MM, Jones LW. American Society of Clinical Oncology position statement on obesity and cancer. Obstetrical & Gynecological Survey. 2015;70(1):28-9. DOI: 10.1097/01.ogx.0000460710.50708.e4
Al-hussaniy HA, Altalebi RR, Tylor FM, Naj MA, Kadhim ZS, Abu-rghaif AH. Leptin Hormone: In Brief. Medical and Pharmaceutical Journal. 2022;1(1):1-3. DOI: 10.55940/medphar20224
Al-hussaniy HA, Al-Shammari AH, Sameer HN, Oraibi AI. The relationship between statin therapy and adipocytokine/inflammatory mediators in dyslipidemic nondiabetic patients: A comparative study. Pharmacia. 2023;70(3):581-5. DOI: 10.3897/pharmacia.70.e109800
Gunter MJ, Xie X, Xue X, Kabat GC, Rohan TE, Wassertheil-Smoller S, Ho GY, Wylie-Rosett J, Greco T, Yu H, Beasley JM, Strickler HD. Breast cancer risk in metabolically healthy but overweight postmenopausal women. Cancer Res. 2015;75(1):270-4. DOI: 10.1158/0008-5472.CAN-14-2317
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. The lancet. 2008;371(9612):569-78.
Xue K, Li FF, Chen YW, Zhou YH, He J. Body mass index and the risk of cancer in women compared with men: a meta-analysis of prospective cohort studies. European Journal of Cancer Prevention. 2017;26(1):94-105. DOI: 10.1097/CEJ.0000000000000231
Aune D, Navarro Rosenblatt DA, Chan DS, Abar L, Vingeliene S, Vieira AR, Greenwood DC, Norat T. Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose‐response meta‐analysis of prospective studies. International journal of cancer. 2015;136(8):1888-98. DOI: 10.1002/ijc.29207
Al-Hussaniy HA, Al-Kuraishy HM, Abdulameer AG. The Use of Panax Ginseng to Reduce the Cardiotoxicity of Doxorubicin and Study its Effect on Modulating Oxidative Stress, Inflammatory, and Apoptosis Pathways. Open Access Macedonian Journal of Medical Sciences. 2022;10(A):715-9. DOI:10.3889/oamjms.2022.9479
Feletto E, Kohar A, Mizrahi D, Grogan P, Steinberg J, Hughes C, Watson WL, Canfell K, Yu XQ. An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017. Lancet Reg Health West Pac. 2022 Sep 6;29:100575. doi: 10.1016/j.lanwpc.2022.100575.
Ko SM, Lee J, Bae SJ, Baik SJ, Ji J, Kim D, Ahn SG, Jeong J. Body mass index and absolute lymphocyte count predict disease-free survival in Korean breast cancer patients. British journal of cancer. 2021;125(1):119-25. DOI: 10.1038/s41416-021-01391-0
Atkinson RL, El-Zein R, Valero V, Lucci A, Bevers TB, Fouad T, Liao W, Ueno NT, Woodward WA, Brewster AM. Epidemiological risk factors associated with inflammatory breast cancer subtypes. Cancer Causes Control. 2016;27(3):359-66. DOI: 10.1007/s10552-015-0712-3.
Ruggiero E, Di Castelnuovo A, Costanzo S, Persichillo M, De Curtis A, Cerletti C, Donati MB, de Gaetano G, Iacoviello L, Bonaccio M. Egg consumption and risk of all-cause and cause-specific mortality in an Italian adult population. European journal of nutrition. 2021;60:3691-702. DOI: 10.1007/s00394-021-02536-w
Nimptsch K, Aleksandrova K, Boeing H, et al. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk. Int J Cancer. 2016;138(6):1422-1431.
DOI: 10.1002/ijc.29086
Shaaban SM, Gaber Z, Semary S, Dewidar AM. Impact of Vitamin B12 on outcome of Early Stage Luminal A and B Breast Cancer, single center experience. Medical and Pharmaceutical Journal. 2023;2(1):17-27. DOI: 10.55940/medphar202227
Tin Tin S, Reeves GK, Key TJ. Body size and composition, physical activity and sedentary time in relation to endogenous hormones in premenopausal and postmenopausal women: findings from the UK Biobank. International Journal of Cancer. 2020;147(8):2101-15. DOI: 10.1002/ijc.33010
Argyrakopoulou G, Dalamaga M, Spyrou N, Kokkinos A. Gender differences in obesity-related cancers. Current obesity reports. 2021;10:100-15. 10.1007/s13679-021-00426-0
Clinton SK, Giovannucci EL, Hursting SD. The world cancer research fund/American institute for cancer research third expert report on diet, nutrition, physical activity, and cancer: impact and future directions. The Journal of nutrition. 2020;150(4):663-71. DOI: 10.1093/jn/nxz268
Pan K, Luo J, Aragaki AK, Chlebowski RT. Weight loss, diet composition and breast cancer incidence and outcome in postmenopausal women. Oncotarget. 2019;10(33):3088. DOI:10.18632/oncotarget.26864
Awad M, Al-hussaniy HA, Alburghaif AH, Tawfeeq KT. The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention. Journal of Medicine and Life. 20220`;15(12):1458-63. DOI: 10.25122/jml-2022-0167
Zuniga PV, Vakil E, Molina S, Bassett Jr RL, Ost DE. Sensitivity of radial endobronchial ultrasound-guided bronchoscopy for lung cancer in patients with peripheral pulmonary lesions: an updated meta-analysis. Chest. 2020 ;157(4):994-1011.
Altalebi RR, Al-Hussaniy HA, Al-Tameemi ZS, Al-Zobaidy MA, Albu-Rghaif AH, Alkuraishy HM, Hedeab GM, Azam F, Al-Samydai AM, Naji MA. Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes. Journal of Medicine and Life. 2023;16(1):42. DOI: 10.25122/jml-2022-0091
Azrad M, Blair CK, Rock CL, Sedjo RL, Wolin KY, Demark-Wahnefried W. Adult weight gain accelerates the onset of breast cancer. Breast cancer research and treatment. 2019;176:649-56. DOI: 10.1007/s10549-019-05268-y
Trauchburg A, Schwingshackl L, Hoffmann G. Association between Dietary Indices and Dietary Patterns and Mortality and Cancer Recurrence among Cancer Survivors: An Updated Systematic Review and Meta-Analysis of Cohort Studies. Nutrients. 2023 ;15(14):3151. DOI: 10.3390/nu15143151
Al-Hussaniy HA, Alburghaif AH, Naji MA. Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions. Journal of Medicine and Life. 2021;14(5):600-5. DOI: 10.25122/jml-2021-0153
Aminian A, Wilson R, Al-Kurd A, Tu C, Milinovich A, Kroh M, Rosenthal RJ, Brethauer SA, Schauer PR, Kattan MW, Brown JC. Association of bariatric surgery with cancer risk and mortality in adults with obesity. Jama. 2022 ;327(24):2423-33. DOI:10.1001/jama.2022.9009
Adams SA, Smith ER, Hardin J, Prabhu‐Das I, Fulton J, Hebert JR. Racial differences in follow‐up of abnormal mammography findings among economically disadvantaged women. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2009 ;115(24):5788-97. DOI: 10.1002/cncr.24633
Zhao N, Huh J, Murphy ST, Chatterjee JS, Baezconde-Garbanati L. Self-Construal as a Predictor of Korean American Women's Intention to Vaccinate Daughters against Human Papillomavirus. Asian American journal of psychology. 2014;5(2):96-105. DOI: doi/10.1037/a0036097
Sinicrope FA, Foster NR, Sargent DJ, O'Connell MJ, Rankin C. Obesity is an independent prognostic variable in colon cancer survivors. Clin Cancer Res. 2010;16(6):1884-1893. DOI:10.1158/1078-0432.
Anderson AS, Caswell S, Wells M, Steele RJ. Obesity and lifestyle advice in colorectal cancer survivors - how well are clinicians prepared?. Colorectal Dis. 2013;15(8):949-957. DOI:10.1111/codi.12203
Anderson AS, Caswell S, Wells M, Steele RJ. Obesity and lifestyle advice in colorectal cancer survivors - how well are clinicians prepared?. Colorectal Dis. 2013;15(8):949-957. DOI:10.1111/codi.12203
Kuk JL, Ardern CI. Are metabolically normal but obese individuals at lower risk for all-cause mortality?. Diabetes Care. 2009;32(12):2297-2299. DOI:10.2337/dc09-0574
Lin JS, Piper MA, Perdue LA, Rutter CM, Webber EM, O’Connor E, Smith N, Whitlock EP. Screening for colorectal cancer: updated evidence report and systematic review for the US Preventive Services Task Force. Jama. 2016;315(23):2576-94. DOI:10.1001/jama.2016.3332
Prado CM, Baracos VE, McCargar LJ, et al. Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity. Clin Cancer Res. 2007;13(11):3264-3268. DOI:10.1158/1078-0432.CCR-06-3067
Barret M, Antoun S, Dalban C, Malka D, Mansourbakht T, Zaanan A, Latko E, Taieb J. Sarcopenia is linked to treatment toxicity in patients with metastatic colorectal cancer. Nutrition and cancer. 2014;66(4):583-9.
Bossi P, Delrio P, Mascheroni A, Zanetti M. The Spectrum of Malnutrition/Cachexia/Sarcopenia in Oncology According to Different Cancer Types and Settings: A Narrative Review. Nutrients. 2021 Jun 9;13(6):1980. DOI: 10.3390/nu13061980.
Healy LA, Ryan AM, Sutton E, Younger K, Mehigan B, Stephens R, Reynolds JV. Impact of obesity on surgical and oncological outcomes in the management of colorectal cancer. International journal of colorectal disease. 2010;25:1293-9.
Acevedo F, Walbaum B, Muñiz S, Petric M, Martínez R, Guerra C, Navarro M, Córdova-Delgado M, Pinto MP, Sánchez C. Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy. Scientific Reports. 2022 Dec 7;12(1):21145. DOI: 10.1038/s41598-022-25043-2
Alkuraishy HM, Al-Gareeb AI, Al-Hussaniy HA. Doxorubicin-induced cardiotoxicity: molecular mechanism and protection by conventional drugs and natural products. Int J Clin Oncol Cancer Res.
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Copyright (c) 2023 JAYHIND LALCHAND BHARTI, Anjali Wankhade, Pratiksha Morey, Prerna Ruikar
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