Synthesis and Free Radical Scavenging Activity of (2e,4e)-1,5-Diphenylpenta-2,4-Dien-1-One Using in Vitro Method
DOI:
https://doi.org/10.55940/medphar202497Keywords:
Chalcone, free radical, Claisen-Schmidt condensation, Nitric oxideAbstract
Background: Chalcone synthesis is an important organic chemistry project with wide-ranging effects on drug discovery, medicinal chemistry, and material science, Chalcones serve as an intermediary product in the synthesis of a number of active substances, including aurones, isoflavonoids, and flavonoids
Objective: To learn more about the impacts of particular substituents, the relationships between the synthesized compounds' characteristics and molecular structures were examined. . The study also clarifies the mechanistic elements of the Claisen-Schmidt condensation processes that are necessary for the synthesis of chalcones
Methods: Using the Claisen-Schmidt condensation reaction, a series of chalcones (1a-1e) were effectively and synthesized by combining acetophenone as the ketone component and different aromatic aldehydes as the carbonyl donors. It was possible to create a library of chalcone derivatives with unique chemical properties by looking at the effects of various aldehydes on the final molecules. Their antioxidant activity was evaluated using the nitric oxide free radical scavenging assay in vitro. Characterization was performed using Fourier Transform Infrared (FTIR) spectroscopy and Thin Layer Chromatography (TLC).
Results: Our newly synthesized compounds (a1-e1) chalcone derivatives show various degrees of antioxidant and free radical scavenging effect. The presence of electron-donating or withdrawing groups significantly affected the biological activity.
Conclusion: In this research, we have manufactured several compounds derived from chalcone by Claisen-Schmidt condensation and after testing them, they showed excellent effectiveness for antioxidant effect and free radical scavenging, However, further in vivo studies such as human pharmacological effect were needed to develop new antioxidant and free radical scavenging drugs in the future.
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Copyright (c) 2025 Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree, Saripella Jaya Sree, Yajali Naga Babu
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